In view of the strategic defense problem, according to different operations two scenes including a single-directional threat and a fan-shaped threat are established, and the incoming targets are intercepted at the middle segment. According to the characteristics of the selected interceptor and the incoming missile, the space killing area of the interceptor mode and the model of protection zone and the covering angle of the ground assets are established, and the weapon deployment model under the two scene defense systems is established. The model is optimized by the comprehensive interception efficiency, the ground assets covering angle, and the deployment cost. The validity of the deployment model method is verified by a concrete example. The research results have certain reference value for the application of antimissile warfare.